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Accueil > Recherche > Les départements scientifiques > Génie des Procédés Membranaires (GPM) > 1. Intensification de procédés

7. Membranes macroporeuses "respirantes".

Modeling the evolution of environmental conditions inside spaces fitted out by a macroporous membrane for the control of gas transfers.

The macroporous membranes (« breathing » membranes) enable to control gaseous exchanges between a closed space and the exterior.

For example, a macroporous membrane may have a significant influence on internal environmental conditions (temperature, relative humidity, pressure) of a motoring electronic calculator, it-self placed in the motor compartment of a car. A precise modeling of transfers allows a representation of the evolution of internal environmental parameters versus external environmental variations.

Another example concerns the closed vessel equipped with a breathing membrane, designed for cellular culture to perform new immunological and toxicity tests aimed to replace in vivo tests on animals. The main role of membrane is on one hand to facilitate permanent gaseous exchanges needed to cellular breathing (O_2, CO_2) and on the other hand to control the loss of the tested aromatic compounds. A 3 D modeling of gaseous and vapor exchanges between the different compartments of the closed space, coupling with the breathing equation for the used mammalian cells (hybridomes souri –souri CRL 1606), was validated by experimental data.

Concentration profiles of butyrate methyl after 48h in 3 compartments of a closed space aimed to be used for toxicity tests. The inferior compartment contains the cell medium ; the intermediate compartment contains saturated air ; the macroporous membrane is schemed by a central circle and the top compartment is flowed from the left to the right by a saturated air flow.

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