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Home > Research > Research departments > Interfaces, Physical Chemistry and Polymers (IP2) > Bioinspired Membranes

Research Activities

by Marc ROLLAND -

(Bio)molecule at solid/liquid interfaces and confinement

We are interested by the phenomena which occurs at solid/liquid interface, more specifically, (bio)macromolecules the protein and dye adsorption. In this field, we work to understand the relationship structure/properties of protein when they are loaded on material. To do so, we develop experimental devices based on time resolved fluorescence and confocal spectroscopy. The solid objects are focus on silicone based, clay, 2D material and nanoparticle. We also interested by the behavior of polyelectrolyte and polymer under confinement. Typically we study the swelling and the organization of macromolecule when they are grafted or adsorbed inside nanopore.
Current projects :

Transport under confinement and nanofluidic

This topic aim to understand the transport phenomena of simple electrolyte (ion), (bio)macromolecules (protein, DNA,), protein aggregate, amyloid and nanoparticle through single nanopore. In this field our activity is focus on solid-state and polymer nanopores with different geometry and surface functionalization. Beside the fundamental aspect, we aim to develop nanopore technology for protein assembly and nanoparticle sensing.
Grants :
Projet NANODIAG grant by la région LR and FEDER (2016-2018), Topic : Detection of biomarker by nanopore as new diagnosis tools
AmiDiag grand by université de Montpellier and LABEX ChemiSyst (2017-2019) Thematique : Single nanopore for amyloid fibril detection

Bio-inspired and biomimetic materials and nanopores

This topic aims to design biomimetic and bio-inspired surface and nanopore. As exemple for the nanopore, we define strategies of functionalization to mimic biological channel in term of selectivity, response against stimuli (pH, light, ligand etc..). Such nanopore can be upscaled to for application in sensor, osmotic energy harvesting, logical circuit. Besides nanopore, we design multifunctional surfaces for biosensing, and health application.

Grants :
SIMI 8 TRANSION (2013-2017) Topic : Study of ionic transport through confined ionic channel

Specific equipment:
Time resolved fluorescence spectroscopy (solution and confocal setup), epifluorescence microscope, diffusion light scattering, patch-clamp amplifier.

Our group collaborates with many groups in france, UE and non UE country.
France: J. Palmeri (L2C, Montpellier) M. Manghi (LPT, Toulouse) et F. Picaud (LNIT, Besançon) MC Clochard et PE Coulomb (LSI, Palaiseau) E Balanzat (CIMAP –Caen) M Jaber (LAMS, UPMC)
UE: A. Kocer Department of Neurosciences, University of Groningen, (Pays-Bas)
Non UE: A. Ben Haj Amara université de l’université de Bizerte (Tunisie) M. Kharroubi université de Djelfa (Algérie) Narayana Kalkura Crystal Growth Centre, Anna University, Chennai, (Inde) L. Dumee Institute for Frontier Materials, Deakin University (Australie)